Synthesis of 3-aryl-4,5-dihydro pyrazole-based and its antibacterial activity
Lina Fauzi^ah, Tutik Dwi Wahyuningsih

Universitas Islam Indonesia, Universitas Gadjah Mada

Abstract

Pyrazoline has been reported with a broad spectrum of biological activity. The presence of withdrawing especially the 4-nitrophenyl group in 1,3,5-triphenylpyrazoline has never been performed. A new derivative of 2-pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly, pyrazoline was synthesized by cyclization of chalcone and hydrazine hydrate without acetate acid as a catalyst. Reactants were refluxed for 30 hours and controlled by Thin Layer Chromatography (TLC). The result showed that reaction yielded 45,07% red solid pyrazoline. Characterization of the structure was confirmed by FTIR and 1H- NMR spectra. However, in vitro antibacterial study showed that the compound has very low antibacterial activity.

Keywords: pyrazole-based, pyrazoline, nitro

Topic: Chemistry