Synthesis of Ethyl Acetoacetate from Ethyl Acetate Using Sodium Ethoxide as a Catalyst
A Kadarohman1,*, AH Salim1, RE Sardjono1, A Pratiwi1, and LL Khumaisah2

1 Department of Chemistry Education, Faculty of Mathematics and Science Education, Universitas Pendidikan Indonesia, Jalan Dr. Setiabudhi No. 229 Bandung 40154, Indonesia

2 Department of Chemistry, Faculty of Science and Technology, Universitas Muhammadiyah Sukabumi, Jalan R. Syamsudin, S.H. No. 50 Sukabumi 43113 Indonesia

Abstract

Ethyl acetoacetate is a perfume compound with the smell fresh floral fruity green. Ethyl acetoacetate can be synthesized from ethyl acetate by the Claisen condensation reaction. This study aims to determine the optimum conditions for the synthesis of ethyl acetoacetate from ethyl acetate with sodium ethoxide as a catalyst. Ethyl acetoacetate synthesis was carried out using the reflux method. Synthesis of ethyl acetoacetate using 0.2 mole of ethyl acetate. The study was conducted with variations in temperature at 78 oC, 80 oC, and 82 oC- variation of ethanol 0.05 mole, 0.1 mole, and 0.15 mole- variations of sodium metal 0.05 mole, 0.1 mole, and 0.15 mole- as well as variations of reaction time 0.5 hours- 1 hour- 1.5 hours- 2 hours- 2.5 hours- 3 hours- 3.5 hours and 4 hours. The reaction products were analyzed using GC and GC-MS. The optimum conditions for the ethyl acetoacetate synthesis reaction were found at a temperature of 82 oC, the ratio of ethyl acetate to ethanol was 2:1, the amount of sodium metal was 0.1 mol and the reaction time for 2 hours with ethyl acetoacetate produced was 91.55%.

Keywords: Ethyl Acetoacetate, Ethyl Acetate, Claisen Condensation, Sodium Ethoxide

Topic: Chemistry