Influence of Lateral Size of Hexagonal Gold Nanoparticles on Enhancing Localized Surface Plasmon Resonance Signal for Albumin Detection
Silva Nurfasha (a), Chandra Wulandari (b),Ahmad Aminuddin (a), Budi Mulyanti (c), Roer Eka Pawinanto (d), and Lilik Hasanah (a*)

(a) Physics Study Program, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi 229 Bandung 40154, Jawa Barat, Indonesia
(b) Doctoral Program of Engineering Physics, Faculty of Industrial Technology, Institut Teknologi Bandung, Ganesha 10, Bandung 40132, Indonesia
(c) Electrical Engineering Education Study Program, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi 229 Bandung 40154, Jawa Barat, Indonesia
(d) Industrial Automation and Robotics Engineering Study Program, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi 229 Bandung 40154, Jawa Barat, Indonesia

Abstract

The kidney organ in humans has a very important role. The damage of kidney will cause the filtering of waste fluids in the body to be disrupted and will cause health complications. Damage to the kidneys is detected by the presence of albumin protein in the urine. Damage to the kidneys can be detected from albumin level, because this protein should be filtered in the kidneys but can be carried in the urine. The use of localized sensor plasma resonance (LSPR) in the field of biosensors to detect albumin protein in urine is the latest breakthrough in the medical field. By using FDTD simulation, the lateral size of hexagonal gold nanoparticles (AuNPs) is varied to increase the optimal LSPR. In several studies, gold material has been the most sensitive material for the use of LSPR. Hexagonal AuNPs were chosen because they can increase the surface area and enhance the LSPR signal. Varying the geometry of the hexagonal AuNPs will affect their sensitivity and optical properties. The lateral size of the hexagonal AuNPs varied from 10 nm to 60 nm, with a constant thickness of 30 nm. The absorption graph shifts towards the left and also decreases until the graph has almost no peak as the lateral size decreases. This effect is then analyzed to determine the optimum geometry of hexagonal gold nanoparticles. Optimization of the geometry of hexagonal AuNPs in this study is expected to significantly improve the performance of LSPR-based sensors for albumin detection.

Keywords: LSPR, hexagonal, gold nanoparticles, albumin, FDTD

Topic: Physic