Systemic Review Article: Composite Hydrogel Based on Chitosan/Polyvinyl alcohol as Drug Delivery Material Riri Uswatun Annifah (1), Asep Kadarohman (1), Fitri Khoerunnisa (1), Mita Nurhayati (1,2), Eli Hendrik Sanjaya (3)
(1)Departement of Chemistry, Indonesia University of Education Setiabudi 229 Bandung 40154 Indonesia
*Fitri[at]upi.edu
(2) Department of Advanced Science and Technology Convergence, Kyungpook National University, Sangju-si, Gyeongsangbuk-do, South Korea
(3) Departement of Chemistry, Universitas Negeri Malang. Jl. Semarang No. 5 Malang 65145, Indonesia
Abstract
Chitosan (CS) and polyvinyl alcohol (PVA) based hydrogels are potential materials for drug delivery applications. This review article aims to examine the synthesis methods, characterization, and effectiveness of CS/PVA hydrogels as drug delivery materials, i.e., nano-insulin, Ibuprofen, and enrofloxacin. Literature search was conducted using ScienceDirect and Google Scholar, selecting articles indexed by Scopus under Q1 and Q2 categories within the past five years. The synthesis of CS/PVA hydrogels was carried out using various methods, including crosslinking, freeze-thaw, and sol-gel. The characteristics of the hydrogels were evaluated using Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), and swelling ratio measurement Performance testing was conducted through drug release studies. The synthesis results indicated that the crosslinking method was the most effective for hydrogel synthesis. Characterization through FTIR spectroscopy revealed the absorption peaks for each precursor, particularly at 1570 cm-1 and 650 cm-1, indicating the presence of aromatic ring C=C and Cl groups. The best swelling ratio was achieved by CS/PVA/Glutaraldehyde/nano-insulin hydrogel, reaching up to 203.3%. The SEM images demonstrated the homogeneous surface of the hydrogel. Among the composite hydrogels, CS/PVA/Glutaraldehyde/nano-insulin showed the highest potential as a drug delivery agent, as demonstrated by the drug release profile with a release percentage of 91.8%.
Keywords: inflammatory, composite hydrogel, CS/PVA, nano-insulin, drug release
