Bioprospection of Noni with Edible Chicken Shank Gelatin Film as Osteoporosis Suplement Virita Rossa Pratiwi (a), Rafida arini (a), Ruly Budiono (a),Yasmi Purnamasari Kuntana (a)*
a) Departement of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University
Jl. Raya Bandung Sumedang Km.21, Jatinangor, Jawa Barat 45363, Indonesia
*Email: y.purnamasari[at]unpad.ac.id
Abstract
Osteoporosis is a degenerative disease in the form of deterioration of body structure and function which was originally dominated by the elderly is now shifting towards a younger age. Until now the pathophysiology has not been perfectly understood. This disease is a silent epidemic disease so it does not cause special symptoms but can be observed through blood and bone tests. Giving gelatin from chicken shank is proven to induce cartilage cell growth while noni contains various active compounds that are able to regulate the process of osteogenesis and increase serum calcium and alkaline phosphatase. This study aimed to see the effect of noni with edible gelatin film on bone tissue and blood of osteoporotic rats. The study was conducted experimentally using a complete randomized design in the laboratory. The treatment consisted of negative control P1 (aquades + glycerol), positive control P2 (dexamethasone + glycerol) and P3-P5 (dexamethasone + noni dose 50- 112- 250 mg/kg body weight per day with edible gelatin film). Dexamethasone 5 mg/kg body weight is injected subcutaneously for a week while Noni and gelatin are administered orally daily for 14 days. The study parameters included blood profile (erythrocyte count, leukocytes, Hb levels, blood calcium, and ALP) as well as femoral bone trabeculae thickness. The results showed that noni administration (doses of 50, 112, and 250 mg/kg body weight) with edible gelatin film increased trabeculae thickness, without changing the number of erythrocytes, leukocytes, blood Hb, Ca levels, and ALP. Thus, it can be concluded that noni and edible gelatin films are safe to give and have the potential as drugs and supplements for people with osteoporosis.
