Comparison Profile of Quality of Life, Phosphorylated-tau, and Superoxide Dismutase Plasma in Women Elderly with and without Dementia Lisna Anisa Fitriana(a), Lina Anisa Nasution(a), Irma Darmawati(a), Linda Amalia(a), Kusnandar Anggadiredja(b), Setiawan(c), Adang Suherman(d), I Ketut Adnyana(b*)
a) Department of Nursing, Faculty of Sport Sciences and Health Education, Universitas Pendidikan Indonesia, Setiabudhi District, No 229, Bandung, 40154
b) Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Ganesha District, No 10, Bandung
*ketut[at]fa.itb.ac.id
c) Department of Physiology, Faculty of Medicine, Universitas Padjadjaran, Bandung-Sumedang District, Km.21, Jatinangor Sumedang, 45363
d) Department of Sport Science, Faculty of Sport Sciences and Health Education, Universitas Pendidikan Indonesia, Setiabudhi District, No 229, Bandung, 40154
Abstract
Accumulation of phosphorylated-tau and low levels of superoxide dismutase is associated with dementia affecting the quality of life in the elderly. This study aimed to determine differences in quality of life (QoL), phosphorylated-tau (p-TAU), and superoxide dismutase (SOD) plasma in women elderly with and without dementia. The research method was a cross-sectional study. Examination of dementia using MMSE (Mini-Mental State Examination) and CDR (Clinical Dementia Rating Scale). The measure of the quality of life using the WHO-QOL questionnaire and plasma level of phosphorylated-tau and SOD using ELISA (Enzyme-linked Immunosorbent Assay). The research sample consisted of 70 women elderly mean aged 74.69 ± 9.27 years who lived in three nursing homes. Data analysis used fisher test, independent sample t-test, Mann-Whitney test, and linear regression test. The results showed that there were significant differences in quality of life in the domain of physic (p=0.001), psychological (p<0.001), social relationship (p=0.002), environment (p<0.001), and plasma level of p-tau (p=0.028) and SOD (p<0.001) in women elderly with and without dementia. In term of its association with dementia, p-tau (p=0.001), SOD (p=0.003), MMSE (p=0.028), and QOL-social relationship (p=0.176) were final model factors of dementia in women elderly. In conclusion, the lowered quality of life and plasma SOD, and the increase of p-tau plasma can use to predictor factors of dementia.
Keywords: dementia- elderly- phosphorylated-tau (p-TAU)- SOD- quality of life (QoL)
