Electrospun Gelatin/Cellulose Acetate as a Carrier of Garcinia mangostana L. Pericarp Extract F H Kusumah (a*), M M Munir (b), and Khairurrijal (b)
a) Department of Physics Education, Faculty of Educational Sciences, Universitas Islam Negeri Syarif Hidayatullah Jakarta
*fujikusumah[at]uinjkt.ac.id
b) Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung
Abstract
Mangosteen or Garcinia mangostana L. pericarp extract (GP) containing α-mangostin has therapeutic potential as an antioxidative agent. However, α-mangostin has low solubility in aqueous solution and is poorly absorbed by the gastrointestinal tract upon oral administration. The solubility of α-mangostin can be enhanced by incorporating GP into nano-sized carriers, such as nanofibers. This study aimed to produce gelatin/cellulose acetate (CA) fibers as a carrier for GP using the electrospinning technique. SEM characterization showed that gelatin/CA fibers at a mass ratio of 6:4 (GC0) had an average diameter of 835 nm. Meanwhile, gelatin/CA/GP fibers generated from precursor solutions with the solution mass ratio of gelatin/CA to GP were 12:1 (GC1), 8:1 (GC2) and 6:1 (GC3), had average diameters of 682, 525 and 359 nm, respectively. The presence of ethanolic GP solution in GC0 precursor solution decreased solution viscosity but increased its conductivity. Furthermore, the FTIR transmission spectra of GP, GC0 and GC2 fibers implied that the incorporation of GP altered the intermolecular interaction of gelatin/CA molecules.
Keywords: Electrospinning, nanofibers, Garcinia mangostana L
