This research was a literature review on science process skills in the 21st century. Science process skills have a relationship with 21st-century abilities, which can improve thinking processes from a concrete level to a complex level. For this reason, it is necessary to discuss comprehensively related science process skills in 21st Century science learning. 21st Century Learning focuses on encouraging students to learn certain skills that can help them respond better to changing social patterns. This study used 5 indexed journals to review science process skill materials in some research. Science process skills are divided into two, namely basic process skills and integrated process skills. Science process skills can be applied properly through inquiry-based learning. Inquiry-based learning acts as a driving factor in developing science process skills in science learning in the 21st century
Keywords: Literatur review- Science Process Skill- 21-st Century Learning
